Recent Publications
Whitaker EE, Mecum NE, Cott RC, Goode DJ. DRG神经元中MHCⅱ的表达可减弱雄性和雌性小鼠紫杉醇诱导的冷超敏反应. PLoS One. 2024 Feb 8;19(2):e0298396. doi: 10.1371/journal.pone.0298396. PMID: 38330029; PMCID: PMC10852343.
Goode DJ. Immunotherapy, a new approach for the treatment of human pain. Pain. 2024 Apr 1;165(4):725-726. doi: 10.1097/j.pain.0000000000003107. Epub 2023 Nov 16. PMID: 37975869.
Fitzsimons LA, Tasouri E, Willaredt MA, Stetson D, Gojak C, Kirsch J, Gardner HAR, Gorgas K, Tucker KL. Primary cilia are critical for tracheoesophageal septation. Dev Dyn. 2024 Mar;253(3):312-332. doi: 10.1002/dvdy.660. Epub 2023 Sep 30. PMID: 37776236; PMCID: PMC10922539.
Fitzsimons LA, Staurengo-Ferrari L, Bogen O, Araldi D, Bonet IJM, Jordan EE, Levine JD, Tucker KL. 初级纤毛及其痛觉感受器中的刺猬信号参与炎症性和神经性疼痛. Res Sq [Preprint]. 2024 Feb 26:rs.3.rs-3812442. doi: 10.21203/rs.3.rs-3812442/v1. PMID: 38464172; PMCID: PMC10925437.
请在稿件中注明COBRE Behavioral Core和NIGMS资助号P30GM145497提供的资金支持, grants, and presentations that include our work.
Past Publications
Robbins A, Kurose M, Winterson BJ, Meng ID. 薄荷醇激活角膜冷细胞可诱导trpm8介导的流泪，但不诱导伤害性反应. Invest Ophthalmol Vis Sci. 2012 Oct 9;53(11):7034-42. doi: 10.1167/iovs.12-10025. PMID: 22952122; PMCID: PMC3471555.
Cao L, Beaulac H, Eurich A. Differential lumbar spinal cord responses among wild type, CD4 knockout, and CD40 knockout mice in spinal nerve L5 transection-induced neuropathic pain. Mol Pain. 2012 Dec 18;8:88. doi: 10.1186/1744-8069-8-88. PMID: 23249743; PMCID: PMC3545955.
Kurose M, Meng ID. 大鼠脊髓三叉神经核角膜干反应神经元对无害冷却的反应. J Neurophysiol. 2013 May;109(10):2517-22. doi: 10.1152/jn.00889.2012. Epub 2013 Feb 27. PMID: 23446686; PMCID: PMC3653041.
Kurose M, Meng ID. Dry eye modifies the thermal and menthol responses in rat corneal primary afferent cool cells. J Neurophysiol. 2013 Jul;110(2):495-504. doi: 10.1152/jn.00222.2013. Epub 2013 May 1. PMID: 23636717; PMCID: PMC3727064.
Meng ID, Kurose M. The role of corneal afferent neurons in regulating tears under normal and dry eye conditions. Exp Eye Res. 2013 Dec;117:79-87. doi: 10.1016/j.exer.2013.08.011. Epub 2013 Aug 28. PMID: 23994439; PMCID: PMC3989072.
Largent-Milnes TM, Brookshire SW, Skinner DP Jr, Hanlon KE, Giuvelis D(1)，李建军，李建军，李建军，李建军，李建军，李建军，李建军，李建军. 构建更好的镇痛药:解决损伤诱导病理的多功能化合物，以提高镇痛疗效，同时消除不必要的副作用. J Pharmacol Exp Ther. 2013 Oct;347(1):7-19. doi: 10.1124/jpet.113.205245. Epub 2013 Jul 16. PMID: 23860305; PMCID: PMC3781412.
Burman MA, Simmons CA, Hughes M, Lei L. Developing and validating trace fear conditioning protocols in C57BL/6 mice. J Neurosci Methods. 2014 Jan 30;222:111-7. doi: 10.1016/j.jneumeth.2013.11.005. Epub 2013 Nov 20. PMID: 24269252; PMCID: PMC3927557.
Cao L, Butler MB. Involvement of microglial CD40 in murine retrovirus-induced peripheral neuropathy. J Neuroimmunol. 2013 Aug 15;261(1-2):37-43. doi: 10.1016/j.jneuroim.2013.04.023. Epub 2013 May 28. PMID: 23726765; PMCID: PMC3729793.
Parlato R, Mandl C, Hölzl-Wenig G, Liss B, Tucker KL, Ciccolini F. CREB/CREM信号对胚胎神经前体增殖和组蛋白乙酰化的调控. Neurogenesis (Austin). 2014 Nov 26;1(1):e970883. doi: 10.4161/23262125.2014.970883. PMID: 27504469; PMCID: PMC4973597.
Burman MA, Erickson KJ, Deal AL, Jacobson RE. 情境恐惧和听觉恐惧条件反射在大鼠围断奶期继续出现. PLoS One. 2014 Jun 30;9(6):e100807. doi: 10.1371/journal.pone.0100807. PMID: 24977415; PMCID: PMC4076234.
Deal AL, Erickson KJ, Bilsky EJ, Hillman SJ, Burman MA. K-12神经科学教育拓展计划:教育学生神经科学的互动活动. J Undergrad Neurosci Educ. 2014 Oct 15;13(1):A8-A20. PMID: 25565921; PMCID: PMC4281050.
Meng ID, Barton ST, Mecum NE, Kurose M. Corneal sensitivity following lacrimal gland excision in the rat. Invest Ophthalmol Vis Sci. 2015 May;56(5):3347-54. doi: 10.1167/iovs.15-16717. PMID: 26024120; PMCID: PMC4453983.
Stevenson GW, Luginbuhl A, Dunbar C, LaVigne J, Dutra J, Atherton P, Bell B, Cone K, Giuvelis D, Polt R, Streicher JM, Bilsky EJ. 混合作用的δ / μ阿片激动剂MMP-2200不产生条件位置偏好，但在大鼠中维持药物自我给药, and induces in vitro markers of tolerance and dependence. Pharmacol Biochem Behav. 2015 May;132:49-55. doi: 10.1016/j.pbb.2015.02.022. Epub 2015 Feb 28. PMID: 25735493; PMCID: PMC4552603.
Lefever M, Li Y, Anglin B, Muthu D, Giuvelis D, Lowery JJ, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Structural Requirements for CNS Active Opioid Glycopeptides. J Med Chem. 2015 Aug 13;58(15):5728-41. doi: 10.1021/acs.jmedchem.5b00014. Epub 2015 Jul 23. PMID: 26125201.
Warner E, Krivitsky R, Cone K, Atherton P, Pitre T, Lanpher J, Giuvelis D, Bergquist I, King T, Bilsky EJ, Stevenson GW. 术后疼痛样状态对大鼠动机行为的评价:足底切开对进行性食物维持反应的影响. Drug Dev Res. 2015 Dec;76(8):432-41. doi: 10.1002/ddr.21284. Epub 2015 Oct 23. PMID: 26494422; PMCID: PMC4715615.
Gazea M, Tasouri E, Tolve M, Bosch V, Kabanova A, Gojak C, Kurtulmus B, Novikov O, Spatz J, Pereira G, Hübner W, Brodski C, Tucker KL, Blaess S. 初级纤毛对声波刺猬介导的胚胎中脑多巴胺能神经发生至关重要. Dev Biol. 2016 Jan 1;409(1):55-71. doi: 10.1016/j.ydbio.2015.10.033. Epub 2015 Nov 2. PMID: 26542012; PMCID: PMC5873949.
Harasawa I, Johansen JP, Fields HL, Porreca F, Meng ID. 选择性切除表达μ-阿片受体的神经元后，吻侧腹内侧髓质的改变. Pain. 2016 Jan;157(1):166-173. doi: 10.1097/j.pain.0000000000000344. PMID: 26335909; PMCID: PMC4829402.
Mecum NE, Russell R, Lee J, Sullivan C, Meng ID. Optogenetic Inhibition of Nav1.8 Expressing Corneal Afferents Reduces Persistent Dry Eye Pain. Invest Ophthalmol Vis Sci. 2021 Nov 1;62(14):15. doi: 10.1167/iovs.62.14.15. PMID: 34787642; PMCID: PMC8606841.
Gazea M, Tasouri E, Heigl T, Bosch V, Tucker KL, Blaess S. 初级纤毛控制中脑多巴胺能神经发生的关键时空窗口的定义. Neurogenesis (Austin). 2016 Oct 20;3(1):e1248206. doi: 10.1080/23262133.2016.1248206. PMID: 28090543; PMCID: PMC5129902.
Burman MA, Szolusha K, Bind R, Kerney K, Boger DL, Bilsky EJ. FAAH inhibitor OL-135 disrupts contextual, but not auditory, fear conditioning in rats. Behav Brain Res. 2016 Jul 15;308:1-5. doi: 10.1016/j.bbr.2016.04.014. Epub 2016 Apr 13. PMID: 27083303; PMCID: PMC4877211.
Hitomi S, Kross K, Kurose M, Porreca F, Meng ID. 吗啡戒断所致三叉神经硬脑膜敏感神经元活化及c-Fos蛋白升高. Cephalalgia. 2017 Apr;37(5):407-417. doi: 10.1177/0333102416648655. Epub 2016 May 6. PMID: 27155000.
Havelin J, Imbert I, Sukhtankar D, Remeniuk B, Pelletier I, Gentry J, Okun A, Tiutan T, Porreca F， King TE. Mediation of Movement-Induced Breakthrough Cancer Pain by IB4-Binding Nociceptors in Rats. J Neurosci. 2017 May 17;37(20):5111-5122. doi: 10.1523/JNEUROSCI.1212-16.2017. Epub 2017 Apr 24. PMID: 28438966; PMCID: PMC5444195.
Davis SM, Rice M, Rudlong J, Eaton V, King T, Burman MA. 新生儿疼痛和压力破坏了大鼠晚年的巴甫洛夫恐惧条件反射和感觉功能:两击模型的证据. Dev Psychobiol. 2018 Jul;60(5):520-533. doi: 10.1002/dev.21632. Epub 2018 May 10. PMID: 29749116; PMCID: PMC6139181.
Wakley AA, Leeming R, Malon J, Arabatzis TJ, Yuen Koh W, Cao L. Contribution of CD137L to Sensory Hypersensitivity in a Murine Model of Neuropathic Pain. eNeuro. 2018 Nov 8;5(5):ENEURO.0218-18.2018. doi: 10.1523/ENEURO.0218-18.2018. PMID: 30417077; PMCID: PMC6223109.
Rieder CA, Rieder J, Sannajust S, Goode DJ, Geguchadze R, Relich RF, Molliver DC, King TE, Vaughn J, May M. A Novel Mechanism for Zika Virus Host-Cell Binding. Viruses. 2019 Nov 28;11(12):1101. doi: 10.3390/v11121101. PMID: 31795144; PMCID: PMC6949893.
Meng ID, Barton ST, Goodney I, Russell R, Mecum NE. Progesterone Application to the Rat Forehead Produces Corneal Antinociception. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1706-1713. doi: 10.1167/iovs.18-26049. PMID: 31013343; PMCID: PMC6736375.
Hatta A, Kurose M, Sullivan C, Okamoto K, Fujii N, Yamamura K, Meng ID. Dry eye sensitizes cool cells to capsaicin-induced changes in activity via TRPV1. J Neurophysiol. 2019 Jun 1;121(6):2191-2201. doi: 10.1152/jn.00126.2018. Epub 2019 Apr 10. PMID: 30969886; PMCID: PMC6620696.
Mecum NE, Cyr D, Malon J, Demers D, Cao L, Meng ID. Evaluation of Corneal Damage After Lacrimal Gland Excision in Male and Female Mice. Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3264-3274. doi: 10.1167/iovs.18-26457. PMID: 31369671; PMCID: PMC6675517.
Huynh PN, Giuvelis D, Christensen S, Tucker KL, McIntosh JM. RgIA4 Accelerates Recovery from Paclitaxel-Induced Neuropathic Pain in Rats. Mar Drugs. 2019 Dec 21;18(1):12. doi: 10.3390/md18010012. PMID: 31877728; PMCID: PMC7024385.
Eaton VE, Pettit S, Elkinson A, Houseknecht KL, King TE, May M. Polymicrobial abscess following ovariectomy in a mouse. BMC Vet Res. 2019 Oct 24;15(1):364. doi: 10.1186/s12917-019-2125-0. PMID: 31651316; PMCID: PMC6814026.
Mustafa R, Kreiner G, Kamińska K, Wood AJ, Kirsch J, Tucker KL, Parlato R. 亨廷顿氏病小鼠临床前模型中多巴胺感觉神经元初级纤毛的靶向缺失. Front Cell Neurosci. 2019 Dec 20;13:565. doi: 10.3389/fncel.2019.00565. PMID: 31920562; PMCID: PMC6936315.
Zuke JT, Rice M, Rudlong J, Paquin T, Russo E, Burman MA. 急性新生儿疼痛对啮齿动物模型促肾上腺皮质激素释放激素表达和幼年焦虑的影响. eNeuro. 2019 Oct 10;6(6):ENEURO.0162-19.2019. doi: 10.1523/ENEURO.0162-19.2019. PMID: 31601633; PMCID: PMC6860982.
Mecum NE, Demers D, Sullivan CE, Denis TE, Kalliel JR, Meng ID. 雄性和雌性小鼠的泪腺切除引起眼部疼痛和焦虑样行为. Sci Rep. 2020 Oct 14;10(1):17225. doi: 10.1038/s41598-020-73945-w. PMID: 33057056; PMCID: PMC7560880.
Stevenson GW, Giuvelis D, Cormier J, Cone K, Atherton P, Krivitsky R, Warner E, St Laurent B, Dutra J, Bidlack JM, Szabò L, Polt R, Bilsky EJ. 混合作用三角洲选择性阿片受体激动剂BBI-11008的行为药理学研究, inflammatory and neuropathic pain, respiration, and drug self-administration. Psychopharmacology (Berl). 2020 Apr;237(4):1195-1208. doi: 10.1007/s00213-019-05449-z. Epub 2020 Jan 7. PMID: 31912192; PMCID: PMC8106974.
Parlato R, Tucker KL. 编辑:神经系统疾病中新出现的细胞应激传感器:靠近核核和初级纤毛. Front Cell Neurosci. 2020 Mar 20;14:64. doi: 10.3389/fncel.2020.00064. PMID: 32265665; PMCID: PMC7100531.
Fitzsimons LA, Brewer VL, Forrester J, Moran AM, Tucker KL. Noninvasive Electrocardiography in the Perinatal Mouse. J Vis Exp. 2020 Jun 12;(160). doi: 10.3791/61074. PMID: 32597855.
Davis SM, Rice M, Burman MA. 在啮齿动物模型中，炎症性新生儿疼痛破坏了母亲的行为和随后的恐惧条件反射. Dev Psychobiol. 2020 Jan;62(1):88-98. doi: 10.1002/dev.21889. Epub 2019 Jul 3. PMID: 31270817; PMCID: PMC7238892.
Davis SM, Burman MA. 母性分离与新生儿疼痛影响雄性和雌性大鼠的晚年恐惧条件反射和躯体感应. Stress. 2021 Sep;24(5):504-513. doi: 10.1080/10253890.2020.1825674. Epub 2020 Oct 12. PMID: 33043804; PMCID: PMC8039057.
Goode DJ, Molliver DC. Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia. J Neurosci. 2021 Mar 31;41(13):2883-2898. doi: 10.1523/JNEUROSCI.2368-20.2021. Epub 2021 Feb 16. PMID: 33593853; PMCID: PMC8018894.
Beckley JT, Pajouhesh H, Luu G, Klas S, Delwig A, Monteleone D, Zhou X, Giuvelis D, Meng ID, Yeomans DC, Hunter JC, Mulcahy JV. Antinociceptive properties of an isoform-selective inhibitor of Nav1.7 derived from saxitoxin in mouse models of pain. Pain. 2021 Apr 1;162(4):1250-1261. doi: 10.1097/j.pain.0000000000002112. PMID: 33086288; PMCID: PMC9359086.
Mecum NE, Russell R, Lee J, Sullivan C, Meng ID. Optogenetic Inhibition of Nav1.8 Expressing Corneal Afferents Reduces Persistent Dry Eye Pain. Invest Ophthalmol Vis Sci. 2021 Nov 1;62(14):15. doi: 10.1167/iovs.62.14.15. PMID: 34787642; PMCID: PMC8606841.
Nguyen LD, Nolte LG, Tan WJT, Giuvelis D, Santos-Sacchi J, Bilsky E, Ehrlich BE. Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice. Sci Rep. 2021 Jan 27;11(1):2372. doi: 10.1038/s41598-021-81650-5. PMID: 33504822; PMCID: PMC7840744.
Beckley JT, Pajouhesh H, Luu G, Klas S, Delwig A, Monteleone D, Zhou X, Giuvelis D, Meng ID, Yeomans DC, Hunter JC, Mulcahy JV. Antinociceptive properties of an isoform-selective inhibitor of Nav1.7 derived from saxitoxin in mouse models of pain. Pain. 2021 Apr 1;162(4):1250-1261. doi: 10.1097/j.pain.0000000000002112. PMID: 33086288; PMCID: PMC9359086.
Payne E, Harrington K, Richard P, Brackin R, Davis R, Couture S, Liff J, Asmus F, Mutina E, Fisher A, Giuvelis D, Sannajust S, Rostama B, King T, Mattei LM, Lee JJ, Friedman ES, Bittinger K, May M, Stevenson GW. 万古霉素对雌性Fischer大鼠持续疼痛刺激和疼痛抑制行为的影响. J Pain. 2021 Nov;22(11):1530-1544. doi: 10.1016/j.jpain.2021.05.003. Epub 2021 May 21. PMID: 34029686; PMCID: PMC8578155.
Goode DJ, Molliver DC. Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia. J Neurosci. 2021 Mar 31;41(13):2883-2898. doi: 10.1523/JNEUROSCI.2368-20.2021. Epub 2021 Feb 16. PMID: 33593853; PMCID: PMC8018894.
Mustafa R, Rawas C, Mannal N, Kreiner G, Spittau B, Kamińska K, Yilmaz R, Pötschke C, Kirsch J, Liss B, Tucker KL, Parlato R. 定向消融分化多巴胺能神经元初级纤毛降低纹状体多巴胺和对代谢应激的反应性. Antioxidants (Basel). 2021 Aug 13;10(8):1284. doi: 10.3390/antiox10081284. PMID: 34439532; PMCID: PMC8389284.
Davis SM, Zuke JT, Berchulski MR, Burman MA. 杏仁核促肾上腺皮质激素释放因子信号是新生儿疼痛后行为障碍的必要条件. Front Physiol. 2021 May 11;12:660792. doi: 10.3389/fphys.2021.660792. PMID: 34045975; PMCID: PMC8144524.
Goode DJ, Whitaker EE, Mecum NE. 卵巢切除术增加雌鼠紫杉醇诱导的机械超敏反应，减少雌鼠背根神经节中抗炎CD4+ T细胞. J Neuroimmunol. 2022 Jun 15;367:577878. doi: 10.1016/j.jneuroim.2022.577878. Epub 2022 Apr 22. PMID: 35509138.
Sullivan C, Lee J, Bushey W, Demers D, Dinsdale S, Lowe K, Olmeda J, Meng ID. Evidence for a phenotypic switch in corneal afferents after lacrimal gland excision. Exp Eye Res. 2022 May;218:109005. doi: 10.1016/j.exer.2022.109005. Epub 2022 Mar 1. PMID: 35240196; PMCID: PMC9993327.
Fitzsimons LA, Brewer VL, Tucker KL. 刺猬形成因子作为产前和产后心脏发育和成熟的关键生长因子:初级纤毛如何介导它们的信号转导. Cells. 2022 Jun 9;11(12):1879. doi: 10.3390/cells11121879. PMID: 35741008; PMCID: PMC9221318.
Coffman JA, Burman MA, Duboué ER. 社论:早期生活压力与免疫和神经系统反应性的发育规划. Front Cell Dev Biol. 2022 Apr 14;10:897251. doi: 10.3389/fcell.2022.897251. PMID: 35493082; PMCID: PMC9047875.
Whitaker EE, Mecum NE, Cott RC, Goode DJ. 主要组织相容性复合体II在背根神经节神经元中的新表达减弱了雄性和雌性小鼠紫杉醇诱导的冷超敏反应. bioRxiv [Preprint]. 2023 Sep 21:2023.03.31.535136. doi: 10.1101/2023.03.31.535136. Update in: PLoS One. 2024 Feb 8;19(2):e0298396. PMID: 37066176; PMCID: PMC10103942.
Gomez K, Santiago U, Nelson TS, Allen HN, Calderon-Rivera A, Hestehave S, Rodríguez Palma EJ, Zhou Y, Duran P, Loya-Lopez S, Zhu E, Kumar U, Shields R, Koseli E, McKiver B, Giuvelis D, Zuo W, Inyang KE, Dorame A, Chefdeville A, Ran D, Perez-Miller S, Lu Y, Liu X, Handoko, Arora PS, Patek M, Moutal A, Khanna M, Hu H, Laumet G, King T, Wang J, Damaj MI, Korczeniewska OA, Camacho CJ, Khanna R. A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2305215120. doi: 10.1073/pnas.2305215120. Epub 2023 Nov 16. PMID: 37972067; PMCID: PMC10666126.
Grlickova-Duzevik E, Reimonn TM, Michael M, Tian T, Owyoung J, McGrath-Conwell A, Neufeld P, Mueth M, Molliver DC, Ward PJ, Harrison BJ. CUGBP elav样rna结合蛋白家族的成员在初级感觉神经元的不同群体中表达. J Comp Neurol. 2023 Oct;531(14):1425-1442. doi: 10.1002/cne.25520. Epub 2023 Jul 8. PMID: 37537886.
Cao L, Bean EN, Malon JT. Preparation of Primary Mixed Glial Cell Cultures from Adult Mouse Spinal Cord Tissue. Curr Protoc. 2023 Apr;3(4):e743. doi: 10.1002/cpz1.743. PMID: 37042635; PMCID: PMC10478014.